Professional medical papers related to cysteine or
glutathione;_WJD_2017-1023_V001R01_IR00_
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Oxidative
stress and ageing： is ageing a cysteine deficiency
syndrome？
[2005];_WJD_2017-1023_V001R01_IR93_
Source (資訊來源):
(e) Everybody
is likely to experience a cysteine deficiency sooner or later
As everybody beyond the fifth decade of life will experience
sooner or later a decrease in muscle function, a decrease in immune function, a
decrease in plasma albumin concentration, and/or an increase in TNF-α
concentration, it is hypothesized that practically everybody experiences sooner
or later an ageing-related deficit in the body cysteine and glutathione
reservoirs that warrants cysteine supplementation. This hypothesis implies that
ageing may be postponed and frailty be avoided to some extent by
supplementation of the ‘paravitamin’ cysteine. It is emphasized, however, that
several details still require more systematic investigation. Although
substantial negative side effects have not been observed in previous studies on
cysteine supplementation, it is felt that the treatment protocols ought to be
further improved to achieve maximum safety and efficacy over long periods of
time. Properly done, cysteine supplementation can reasonably be expected to
improve the quality of life in old age. With the availability of novel cysteine delivery systems with minimum
amounts of calories, which are superior to any of the naturally available
cysteine sources, it is
conceivable that even the maximum human life span may be increased beyond the
previous limit.
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Elevation of Glutathione as a Therapeutic
Strategy in Alzheimer Disease [2011];_WJD_2017-1023_V001R01_IR93_
Source (資訊來源):
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Glutathione Synthesis Is Diminished in
Patients With Uncontrolled Diabetes and Restored by Dietary Supplementation
With Cysteine and Glycine [2010];_WJD_2017-1023_V001R01_IR93_
Source (資訊來源):
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Crosstalk
between cystine and glutathione is critical for the regulation of amino acid
signaling pathways and ferroptosis [2016];_WJD_2017-1023_V001R01_IR93_
Source (資訊來源):
The
ability of cells to sense and respond to nutrient availability is critical for
cell survival. It is well-established that essential amino acids are
required for the regulation of protein translation and growth. Although
cysteine is not considered an essential amino acid, cysteine
deficiency is
associated with various diseases including metabolic disorders, immune
dysfunction, and cancer.
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Zinc-Binding
Cysteines: Diverse Functions and Structural Motifs
[2014];_WJD_2017-1016_V001R01_IR93_
Source (資訊來源):
Info cited on 2017-10-16-WD1 (資訊引用於 中華民國106年10月16日) by 湯偉晉
(WeiJin Tang)
#
Cysteine residues are known to perform essential functions
within proteins, including binding to various metal ions. In particular,
cysteine residues can display high affinity toward zinc ions (Zn2+), and these
resulting Zn2+-cysteine complexes are critical mediators of protein structure,
catalysis and regulation.
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Glutathione： a molecular whistleblower for Alzheimer’s disease [2015];_WJD_2017-1013_V001R01_IR93_
Source (資訊來源):
Info cited on 2017-10-13-WD5 (資訊引用於 中華民國106年10月13日) by 湯偉晉
(WeiJin Tang)
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Depletion
of reduced glutathione, ascorbic acid, vitamin E and antioxidant defence
enzymes in a healing cutaneous wound.
[1997];_WJD_2017-1023_V001R01_IR92_
Source (資訊來源):
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DNA recognition by Cys2His2 zinc finger proteins.
[2000];_WJD_2017-1023_V001R01_IR93_
Source (資訊來源):
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Endogenous Glutathione Conjugates： Occurrence and Biological Functions [1998];_WJD_2017-1023_V001R01_IR93_
Source (資訊來源):
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The role
of glutathione in copper metabolism and toxicity.
[1989];_WJD_2017-1023_V001R01_IR92_
Source (資訊來源):
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Central nervous system uptake of intranasal glutathione in
Parkinson’s disease [2016];_WJD_2017-1023_V001R01_IR93_
Source (資訊來源):
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Neuroprotection
against neuroblastoma cell death induced by depletion of mitochondrial
glutathione [2013];_WJD_2017-1023_V001R01_IR93_
Source (資訊來源):
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Mitochondrial
glutathione pool is vital in protecting cells against oxidative stress as the
majority of the cellular reactive oxygen species are generated in mitochondria.
Oxidative stress is implicated as a causative factor in neuronal death in
neurodegenerative disorders. We hypothesized that depletion of mitochondrial
glutathione leads to mitochondrial dysfunction and apoptotic death of SK-N-SH
(human neuroblastoma) cells and investigated the neuroprotective strategies
against GSH depletion.
…
Our data suggest that depletion of mitochondrial glutathione
leads to mitochondrial dysfunction and apoptosis. The study indicates that preventing mitochondrial
glutathione depletion could become a novel strategy for the development
of neuroprotective therapeutics in neurodegenerative disorders.
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Glutathione
as a Redox Biomarker in Mitochondrial Disease—Implications for Therapy
[2017];_WJD_2017-1023_V001R01_IR93_
Source (資訊來源):
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Glutathione
in Parkinson's Disease [2016]; Ph.D. dissertation, University of Washington_WJD_2017-1023_V001R01_IR93_
Source (資訊來源):
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