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Oxygen Poisoning and X-irradiation: A Mechanism in Common [1954~2010](IR92)
Sci. Aging Knowl. Environ., 27 April 2005
Vol. 2005, Issue 17, p. cp1
CLASSIC PAPERS
Oxygen Poisoning and X-irradiation: A Mechanism in Common
R. Gerschman, D. L. Gilbert, S. W. Nye, P. Dwyer, and W. O. Fenn
Abstract:
A consideration of various isolated reports in the literature has led us to the hypothesis that oxygen poisoning and radiation injury have at least one common basis of action, possibly through the formation of oxidizing free radicals. This article reviews the pertinent material that led to this hypothesis and also presents the supporting evidence obtained from (i) experiments on the protective action against oxygen poisoning by substances of varied chemical nature known to increase resistance to irradiation, and (ii) experiments on the survival in oxygen of mice irradiated and exposed to high oxygen tensions simultaneously or at different intervals.
Reproduced by permission.
R. Gerschman, D. L. Gilbert, S. W. Nye, P. Dwyer, W. O. Fenn, Oxygen Poisoning and X-irradiation: A Mechanism in Common. Science 119, 623-626 (1954).
Citation: R. Gerschman, D. L. Gilbert, S. W. Nye, P. Dwyer, W. O. Fenn, Oxygen Poisoning and X-irradiation: A Mechanism in Common. Sci. Aging Knowl. Environ. 2005 (17), cp1 (2005).
Sci. Aging Knowl. Environ., 27 April 2005
Vol. 2005, Issue 17, p. cp1
CLASSIC PAPERS
Oxygen Poisoning and X-irradiation: A Mechanism in Common
R. Gerschman, D. L. Gilbert, S. W. Nye, P. Dwyer, and W. O. Fenn
Abstract:
A consideration of various isolated reports in the literature has led us to the hypothesis that oxygen poisoning and radiation injury have at least one common basis of action, possibly through the formation of oxidizing free radicals. This article reviews the pertinent material that led to this hypothesis and also presents the supporting evidence obtained from (i) experiments on the protective action against oxygen poisoning by substances of varied chemical nature known to increase resistance to irradiation, and (ii) experiments on the survival in oxygen of mice irradiated and exposed to high oxygen tensions simultaneously or at different intervals.
Reproduced by permission.
R. Gerschman, D. L. Gilbert, S. W. Nye, P. Dwyer, W. O. Fenn, Oxygen Poisoning and X-irradiation: A Mechanism in Common. Science 119, 623-626 (1954).
Citation: R. Gerschman, D. L. Gilbert, S. W. Nye, P. Dwyer, W. O. Fenn, Oxygen Poisoning and X-irradiation: A Mechanism in Common. Sci. Aging Knowl. Environ. 2005 (17), cp1 (2005).
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