Clinical significance of the glutathione-conjugating system. [1983](IR91)

Clinical significance of the glutathione-conjugating system. [1983](IR91)

// - - Begin memo item - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - //
(Memo Item created on June 11, 2011 03:35 PM)
- - - Begin title or keyword:
Clinical significance of the glutathione-conjugating system.

http://www.ncbi.nlm.nih.gov/pubmed/6338534
- - - End title or keyword:

Pharmacol Res Commun. 1983 Jan;15(1):1-13.
Clinical significance of the glutathione-conjugating system.
Siegers CP, Younes M.

Abstract
Glutathione displays important functions in living cells of many species, human included. Apart from its direct antioxidative activity, which supports the maintenance of the reduced state of proteinthiols, and its possible role in amino acid transport across membranes, it appears to exert several detoxification functions. These include the conjugation of electrophilic compounds and the reduction of H2O2 and lipid hydroperoxides. Disorders in GSH synthesis and metabolism are known and produce hemolysis (溶血; 紅血球溶解) in the first place. Little data exist concerning GSH and the GSH-dependent enzymes involved in its various functions in normal and diseased human tissues. The aim of this review is to stimulate research in this area.

PMID: 6338534 [PubMed - indexed for MEDLINE]
Publication Types, MeSH Terms, Substances
// - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - End memo item - - //

// - - Begin memo item - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - //
(Memo Item created on June 11, 2011 03:43 PM)
- - - Begin title or keyword:
electrophilic
- - - End title or keyword:

electrophilic
親電子的; 吸電子的

In chemistry, an electrophile (literally electron-lover) is a reagent attracted to electrons that participates in a chemical reaction by accepting an electron pair in order to bond to a nucleophile. Because electrophiles accept electrons, they are Lewis acids (see acid-base reaction theories).
// - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - End memo item - - //