Glutathione and GSH-dependent enzymes in the human gastric mucosa [1984](IR92)

Glutathione and GSH-dependent enzymes in the human gastric mucosa [1984](IR92)

// - - Begin memo item - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - //
(Memo Item created on June 7, 2011 12:28 AM)
- - - Begin title or keyword:
Glutathione and GSH-dependent enzymes in the human gastric mucosa [1984](IR92)

http://www.springerlink.com/content/u521475854l70rqk/
- - - End title or keyword:

BIOMEDICAL AND LIFE SCIENCES
JOURNAL OF MOLECULAR MEDICINE
Volume 62, Number 4, 183-186, DOI: 10.1007/BF01731642
ORIGINALIEN
Glutathione and GSH-dependent enzymes in the human gastric mucosa
R. Hoppenkamps, E. Thies, M. Younes and C. -P. Siegers

Abstract
The -glutamyl-transferase activity, the total glutathione content, the GSH-peroxidase activity, and the GSH S-transferase activity using an aryl substrate were estimated in the S9 fraction of gastric biopsy specimens taken from patients with normal stomach morphology (n=24), acute gastritis (n=15), chronic-atrophic gastritis (n=10), gastric ulcer (n=9), and carcinoma of the stomach (n=12). The total glutathione content of normal gastric mucosal specimens was significantly higher than that of human liver biopsy specimens, whereas the GSH-peroxidase and the GSH S-aryltransferase activities were much lower than those found in the liver. Specimens of gastric ulcer had significantly lower enzyme activities of GSH-peroxidase and GSH-aryltransferase, whereas gastric cancer tissue had significantly lower concentrations of total glutathione. The intraindividual comparison of tumorous and non-tumorous tissue showed a consistent decrease of total glutathione as well as of GSH-aryltransferase activity in carcinomatous tissue.

Key words  Glutathione - GSH-peroxidase - GSH S-aryltransferase - Human gastric mucosa - Gastric carcinoma

// - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - End memo item - - //